After checking the IPC analysis, the reaction combination was purified by a TFF system using a Sartocon Slice 200 ECO Hydrosart membrane (30 kDa; Sartorius) and conjugation buffer while DF buffer at an antibody concentration of 6

After checking the IPC analysis, the reaction combination was purified by a TFF system using a Sartocon Slice 200 ECO Hydrosart membrane (30 kDa; Sartorius) and conjugation buffer while DF buffer at an antibody concentration of 6.8 mg/mL to afford linker reoxidation product 4 (1.78 g, 100% yield) in conjugation Continue Reading

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Fourth, mice lack nigrostriatal DA projections throughout development, which may favor the conditions for LID induction, as human PD patients with early-age onset and children with an impaired ability to produce DA show more pronounced LID than those who develop the condition later in life (16, 17)

Fourth, mice lack nigrostriatal DA projections throughout development, which may favor the conditions for LID induction, as human PD patients with early-age onset and children with an impaired ability to produce DA show more pronounced LID than those who develop the condition later in life (16, 17). cholinergic neurons contributes Continue Reading

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The active fractions from size-exclusion were loaded into a Mono S column or Sulfopropyl sepharose fast flow (SPFF) for further purification

The active fractions from size-exclusion were loaded into a Mono S column or Sulfopropyl sepharose fast flow (SPFF) for further purification. higher affinities to DNA substrates. In a dimeric enzyme, the two active sites work in tandem, with the faster site functioning before the slower one, and in the monomeric Continue Reading

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These antibodies have been shown to be able to recognize CD1d loaded with -GalCer and its analogs, while they do not recognize glycosyl ceramides having a -linked sugars moiety (iGb3, -GalCer (24:1), -psychosine, -GluCer, -glucopsychosine) or non-glycosyl ceramides (GalA-GAL, BbGL-2c, Glc-DAG-s2) that can be identified by the TCR of iNKT cells (26, 28, 29)

These antibodies have been shown to be able to recognize CD1d loaded with -GalCer and its analogs, while they do not recognize glycosyl ceramides having a -linked sugars moiety (iGb3, -GalCer (24:1), -psychosine, -GluCer, -glucopsychosine) or non-glycosyl ceramides (GalA-GAL, BbGL-2c, Glc-DAG-s2) that can be identified by the TCR of iNKT Continue Reading

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