Work inside our laboratory offers demonstrated that, when targeting a membrane-distal epitope for the receptor tyrosine kinase ROR1, which is expressed on many stable tumors, CARs having a shortened extracellular spacer conferred first-class reputation of ROR1+ tumor cells and induction of T cell effector function set alongside the same scFv with an extended spacer [51]

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Work inside our laboratory offers demonstrated that, when targeting a membrane-distal epitope for the receptor tyrosine kinase ROR1, which is expressed on many stable tumors, CARs having a shortened extracellular spacer conferred first-class reputation of ROR1+ tumor cells and induction of T cell effector function set alongside the same scFv Continue Reading