Particularly, we detected a significant reduction in the phosphorylation degrees of PI3K at Y458, a phospho-site correlated with the activation degrees of the enzyme [42], AKT at T308 and S473 indicating its reduced activation, and mechanistic target of rapamycin, mTOR, at S2448 resulting in its inactivation [43,44]

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Particularly, we detected a significant reduction in the phosphorylation degrees of PI3K at Y458, a phospho-site correlated with the activation degrees of the enzyme [42], AKT at T308 and S473 indicating its reduced activation, and mechanistic target of rapamycin, mTOR, at S2448 resulting in its inactivation [43,44]. Activation from the Continue Reading