We have previously observed that enforced expression, through transgenesis, of another uracil-excision enzyme (single-stranded monofunctional uracil DNA glycosylase [SMUG] 1) only partially rescues switch recombination in B cells ofung/msh2/mice (9). for specific recruitment of the uracil-excision enzyme or for it to be active on single-stranded DNA. Functional immunoglobulin genes are Continue Reading