Thus, hepcidin expression during inflammation needs to be finely regulated. regulates Tmprss6 expression directly by binding to a Stat5 element located on the Tmprss6 promoter. Importantly, our results spotlight the functional role of inflammatory modulation ofTMPRSS6expression in the regulation of hepcidin. TMPRSS6 inhibition via decreased STAT5 phosphorylation may be an Continue Reading