We found positive correlations of PD-1+ cTFH cells and Env-specific cTFH cells with LN-TFH cells as early as day 3 following immunizations, supporting the notion that LN and circulating TFH cellular populations are related. (GC) B cell affinity maturation. Circulating CXCR5+ CD4+ T (cTFH) cells have supported memory B cell Continue Reading
Lipid Metabolism
A pharmacodynamic model injecting man C57/BL6 mice with IL-15/IL-15R or IL-15, with or without Disk0280, and assessing adjustments in lymphocytic cell serum and populations cytokines was utilized
A pharmacodynamic model injecting man C57/BL6 mice with IL-15/IL-15R or IL-15, with or without Disk0280, and assessing adjustments in lymphocytic cell serum and populations cytokines was utilized. KEY RESULTS Disk0280 inhibited the binding of IL-15 to IL-15R and potently inhibits IL-15 dependent proliferation of cells expressing IL-15R also, shared interleukin Continue Reading