Gonzales utilized a similar ELISA assay to detect low molecular weight A1-42 formed by dissolving A1-42 in HFIP with dilution to 200 nM in PBS (pH 7

Gonzales utilized a similar ELISA assay to detect low molecular weight A1-42 formed by dissolving A1-42 in HFIP with dilution to 200 nM in PBS (pH 7.2) and incubation at 37 C for 24 h [133]. However, A monomer can self-assemble via a nucleation-dependent pathway into A oligomers, larger A Continue Reading

Rape AD, Guo W-H, Wang Y-L

Rape AD, Guo W-H, Wang Y-L. of cells. Homeostasis, a critical biological process to stabilize whole-cell/tissue physiology against external perturbations, has been generally investigated at the cellular level and beyond6-7. Yet, it remains elusive how homeostasis, as a cell-driven biological property, arise from collective, dynamic subcellular events. Understanding homeostasis down Continue Reading

[PubMed] [Google Scholar] 36

[PubMed] [Google Scholar] 36. of integrin manifestation, we discovered that inhibition of lysosome activity rescued integrin manifestation in PHLPP overexpressing cells, therefore recommending that PHLPP adversely settings cell motility by inhibiting Akt activity to market lysosome-dependent degradation of integrins. Functionally, the improved cell migration seen in PHLPP knockdown cells was Continue Reading