[PubMed] [Google Scholar] 36. of integrin manifestation, we discovered that inhibition of lysosome activity rescued integrin manifestation in PHLPP overexpressing cells, therefore recommending that PHLPP adversely settings cell motility by inhibiting Akt activity to market lysosome-dependent degradation of integrins. Functionally, the improved cell migration seen in PHLPP knockdown cells was Continue Reading