Moreover, caspase 9 and caspase 3 activation are primarily reliant on ERK1/2 phosphorylation in BL-EI001-induced apoptosis and in addition nearly disappeared with siRNA (Shape ?(Shape7C),7C), recommending that BL-EI001-induced apoptosis may be reliant on ERK phosphorylation. Open in another window Figure 7 BL-EI001-induced apoptosis is definitely controlled by novel ERK-mediated pathways(A) Continue Reading