Matrigel invasion was assessed using IGF-1 (10nM) while chemoattractant in a 48h timepoint. Abl kinases. We demonstrate that BRAFV600E/ERK play a crucial part in binding, phosphorylating, and regulating Abl localization and Abl/Arg activation by Src Family members Kinases (SFKs). Significantly, Abl/Arg activation downstream of BRAFV600E offers natural and practical significance, Continue Reading