Cell Metab. 11, 364C378 [PMC free article] [PubMed] [Google Scholar] 41. and inactivated glycogen synthase. Treatment of FIH-1-transduced HCEKs with either a myristolated Akt or a GSK-3 inhibitor restored glycogen stores, confirming the direct involvement of Akt/GSK-3 signaling. Silencing FIH-1 in HCEKs reversed the observed changes in Akt-signaling. Glycogen regulation Continue Reading