Although proteasome 5 subunit overexpression as well as the induction of autophagy with a proteasome inhibitor have already been connected with resistance in multiple myeloma (MM) cells [45,46,47], our results showed that there is zero obvious change in the expression degree of the proteasome 5 subunit, inhibition degree of proteasome 5 subunit activity, or amount of autophagy induction by ixazomib and bortezomib

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Although proteasome 5 subunit overexpression as well as the induction of autophagy with a proteasome inhibitor have already been connected with resistance in multiple myeloma (MM) cells [45,46,47], our results showed that there is zero obvious change in the expression degree of the proteasome 5 subunit, inhibition degree of proteasome Continue Reading