This revealed that IKBKE may also modulate the transcriptional activity of the AR independent of its influence on endogenous AR mRNA expression using a robust decrease in PSA protein amounts getting observed with IKBKE knockdown despite the fact that AR-GFP expression was unaffected (Figure ?(Amount3A;3A; Supplementary Amount S3C)

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This revealed that IKBKE may also modulate the transcriptional activity of the AR independent of its influence on endogenous AR mRNA expression using a robust decrease in PSA protein amounts getting observed with IKBKE knockdown despite the fact that AR-GFP expression was unaffected (Figure ?(Amount3A;3A; Supplementary Amount S3C). tumour size Continue Reading